Merchant R N, Prabhu S R, Kessel E
Obstetrics and Gynecology, B.Y.L. Nair Hospital, Bombay, India.
Int J Fertil Menopausal Stud. 1995 Jan-Feb;40(1):47-54.
To determine the effect on tubal closure of intrauterine quinacrine by dose and time from administration.
Subjects included 33 women of reproductive age who were awaiting hysterectomy for nonmalignant conditions at a Bombay, India medical college. Ten women received 252 mg quinacrine as pellets using a modified Copper-T IUD inserter followed by hysterectomy within 6 weeks, and 23 women received 324 mg quinacrine followed by hysterectomy 6 to 20 weeks post-insertion. Hysterosalpingograms were done before insertion, prior to surgery and on the fresh surgical specimen. The uteri and tubes were subjected to histology studies, including grading of tubal damage. For study of dose, an additional 7 women receiving 100 mg quinacrine (and previously reported) were included.
Tubal closure rates by hysterosalpingogram and tubal histology.
Tubal closures were directly related to quinacrine dose and length of insertion-hysterectomy interval. For the 252 mg quinacrine dose, 55.0% of intramural tubal segments and 5.9% of isthmic segments showed histologic evidence of closure. For the 324 mg dose, all intramural tubal segments and 58.8% of isthmic segments showed histologic evidence of closure. Clinical conditions, such as dysfunctional uterine bleeding, were associated with lower tubal closure rates. Multivariate discriminant analysis showed quinacrine dose to be more important than quinacrine-hysterectomy interval.
确定宫腔内注射阿的平的剂量及给药后时间对输卵管闭合的影响。
研究对象包括33名育龄妇女，她们在印度孟买一所医学院因非恶性疾病等待子宫切除术。10名妇女使用改良的铜T型宫内节育器插入器接受252毫克阿的平丸剂注射，随后在6周内进行子宫切除术；23名妇女接受324毫克阿的平注射，在插入后6至20周进行子宫切除术。在插入前、手术前及新鲜手术标本上进行子宫输卵管造影。对子宫和输卵管进行组织学研究，包括输卵管损伤分级。为研究剂量，纳入另外7名接受100毫克阿的平注射的妇女（此前已报道）。
子宫输卵管造影及输卵管组织学检查的输卵管闭合率。
输卵管闭合与阿的平剂量及插入至子宫切除的间隔时间直接相关。对于252毫克阿的平剂量，55.0%的输卵管壁内段和5.9%的峡部段有组织学闭合证据。对于324毫克剂量，所有输卵管壁内段和58.8%的峡部段有组织学闭合证据。功能失调性子宫出血等临床情况与较低的输卵管闭合率相关。多变量判别分析显示，阿的平剂量比阿的平至子宫切除的间隔时间更重要。
