胆碱能和肾上腺素能激动剂对豚鼠和小鼠下颌下腺液体及蛋白质分泌的影响。

Effects of cholinergic and adrenergic agonists on the secretion of fluid and protein by submandibular glands of the guinea-pig and the mouse.

作者信息

Iwabuchi Y, Iwasaki S, Masuhara T

机构信息

Department of Dental Pharmacology, School of Dentistry, Nippon Dental University, Niigata, Japan.

出版信息

Comp Biochem Physiol Pharmacol Toxicol Endocrinol. 1994 Feb;107(2):185-93. doi: 10.1016/1367-8280(94)90040-x.

DOI:10.1016/1367-8280(94)90040-x

PMID:7749586

Abstract

Significant differences were observed between the guinea-pig and the mouse in terms of the secretion of fluid, protein and secretory granules from submandibular glands in response to pilocarpine, phenylephrine and isoproterenol. In both the guinea-pig and the mouse, the secretory responses induced by pilocarpine, phenylephrine and isoproterenol were inhibited by pretreatment with 4-DAMP, phentolamine and propranolol, respectively. The results suggest that the submandibular glands of the guinea-pig and the mouse have M3-cholinoreceptors, as well as alpha- and beta-adrenoceptors, and that these receptors play different roles in the secretion of fluid, protein and secretory granules from guinea-pig and mouse submandibular glands.

摘要

在毛果芸香碱、去氧肾上腺素和异丙肾上腺素作用下，观察到豚鼠和小鼠下颌下腺在液体、蛋白质和分泌颗粒分泌方面存在显著差异。在豚鼠和小鼠中，毛果芸香碱、去氧肾上腺素和异丙肾上腺素诱导的分泌反应分别被4-二甲基氨基吡啶、酚妥拉明和普萘洛尔预处理所抑制。结果表明，豚鼠和小鼠的下颌下腺具有M3胆碱能受体以及α和β肾上腺素能受体，并且这些受体在豚鼠和小鼠下颌下腺的液体、蛋白质和分泌颗粒分泌中发挥不同作用。