Iwabuchi Y, Iwasaki S, Masuhara T
Department of Dental Pharmacology, School of Dentistry, Nippon Dental University, Niigata, Japan.
Comp Biochem Physiol Pharmacol Toxicol Endocrinol. 1994 Feb;107(2):185-93. doi: 10.1016/1367-8280(94)90040-x.
Significant differences were observed between the guinea-pig and the mouse in terms of the secretion of fluid, protein and secretory granules from submandibular glands in response to pilocarpine, phenylephrine and isoproterenol. In both the guinea-pig and the mouse, the secretory responses induced by pilocarpine, phenylephrine and isoproterenol were inhibited by pretreatment with 4-DAMP, phentolamine and propranolol, respectively. The results suggest that the submandibular glands of the guinea-pig and the mouse have M3-cholinoreceptors, as well as alpha- and beta-adrenoceptors, and that these receptors play different roles in the secretion of fluid, protein and secretory granules from guinea-pig and mouse submandibular glands.
在毛果芸香碱、去氧肾上腺素和异丙肾上腺素作用下，观察到豚鼠和小鼠下颌下腺在液体、蛋白质和分泌颗粒分泌方面存在显著差异。在豚鼠和小鼠中，毛果芸香碱、去氧肾上腺素和异丙肾上腺素诱导的分泌反应分别被4-二甲基氨基吡啶、酚妥拉明和普萘洛尔预处理所抑制。结果表明，豚鼠和小鼠的下颌下腺具有M3胆碱能受体以及α和β肾上腺素能受体，并且这些受体在豚鼠和小鼠下颌下腺的液体、蛋白质和分泌颗粒分泌中发挥不同作用。
