Branca D, Vincenti E, Scutari G
Dipartimento di Chimica Biologica, Università di Padova, Italy.
Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1995 Jan;110(1):41-5. doi: 10.1016/0742-8413(94)00078-o.
The influence of the anesthetic 2,6-diisopropylphenol on isolated rat heart mitochondria has been investigated at a range of concentrations encompassing high and low clinical values. Low clinical concentrations of the anesthetic appeared unable to affect both oxidative phosphorylation and calcium homeostasis. 2,6-diisopropylphenol at high clinical levels decreased both the transmembrane electrical potential and the synthesis of ATP, while leaving mitochondrial calcium homeostasis unaffected. The results obtained suggest that isolated heart mitochondria are substantially insensitive to low clinical concentrations of 2,6-diisopropylphenol, thus largely excluding the possibility that mitochondrial alterations might be involved in the cardiac depression induced by this anesthetic.
在涵盖高、低临床值的一系列浓度范围内，研究了麻醉剂2,6 - 二异丙基苯酚对离体大鼠心脏线粒体的影响。低临床浓度的麻醉剂似乎无法影响氧化磷酸化和钙稳态。高临床水平的2,6 - 二异丙基苯酚降低了跨膜电位和ATP的合成，而线粒体钙稳态未受影响。所得结果表明，离体心脏线粒体对低临床浓度的2,6 - 二异丙基苯酚基本不敏感，因此很大程度上排除了线粒体改变可能参与这种麻醉剂所致心脏抑制的可能性。
