Wagtmann N, Biassoni R, Cantoni C, Verdiani S, Malnati M S, Vitale M, Bottino C, Moretta L, Moretta A, Long E O
Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA.
Immunity. 1995 May;2(5):439-49. doi: 10.1016/1074-7613(95)90025-x.
Recognition of major histocompatibility class I molecules on target cells by natural killer (NK) cells confers selective protection from NK-mediated lysis. Cross-linking of the p58 NK receptor, involved in the recognition of HLA-C alleles, delivers a negative signal that prevents target cell lysis. Molecular cloning of the p58 NK receptor reported here revealed a new member of the immunoglobulin superfamily. Five distinct p58 receptors, with sequence diversity in the immunoglobulin-related domains, were identified in a single individual. All NK clones tested expressed at least one p58 member. Three different types of transmembrane and cytoplasmic domains exist, even among receptors with closely related extracellular domains. These data revealed a repertoire of NK cells with clonally distributed p58 receptors exhibiting diversity in both extracellular and intracellular domains.
自然杀伤（NK）细胞对靶细胞上主要组织相容性复合体I类分子的识别赋予了对NK介导的细胞裂解的选择性保护。参与识别HLA - C等位基因的p58 NK受体的交联传递一个负信号，可阻止靶细胞裂解。本文报道的p58 NK受体的分子克隆揭示了免疫球蛋白超家族的一个新成员。在一个个体中鉴定出五个不同的p58受体，它们在免疫球蛋白相关结构域中具有序列多样性。所有测试的NK克隆至少表达一个p58成员。即使在细胞外结构域密切相关的受体中，也存在三种不同类型的跨膜和细胞质结构域。这些数据揭示了具有克隆分布的p58受体的NK细胞库，其在细胞外和细胞内结构域均表现出多样性。
