Ou S F, Chi C S, Shian W J, Mak S C, Wong T T
Department of Pediatrics, Taichung Veterans General Hospital, Taiwan, R.O.C.
Zhonghua Yi Xue Za Zhi (Taipei). 1995 Feb;55(2):203-8.
Multiple etiological factors have been associated with infantile spasms (IS), and are usually linked to diffuse or multifocal brain damage. It is generally believed that infants with symptomatic IS have a significantly higher incidence of mental retardation and epilepsy than those with cryptogenic IS. However, IS secondary to focal brain lesions in which surgical removal of the lesions has resulted in cessation of generalized spasms and subsequent normal development are rarely reported. A seven-month-old male infant who manifested head nodding and generalized flexor spasms one month prior to the admission is reported. Waking interictal electroencephalography revealed a pattern of burst-suppression variant of hypsarrhythmia. Brain magnetic resonance imaging disclosed a huge porencephalic cyst over the left temporo-parietal region. The infant underwent craniotomy with corpus callosotomy, causing marked improvement in seizures. He attained subsequent stable psychomotor development.
多种病因与婴儿痉挛症（IS）相关，且通常与弥漫性或多灶性脑损伤有关。一般认为，有症状的婴儿痉挛症患儿智力发育迟缓及癫痫的发病率显著高于隐源性婴儿痉挛症患儿。然而，继发于局灶性脑病变且手术切除病变后全身痉挛停止并随后正常发育的婴儿痉挛症鲜有报道。本文报告一名7个月大男婴，入院前1个月出现点头及全身性屈肌痉挛。清醒期发作间期脑电图显示高峰失律的爆发抑制变异型。脑磁共振成像显示左侧颞顶叶区域有一个巨大的脑穿通畸形囊肿。该婴儿接受了胼胝体切开术的开颅手术，癫痫症状明显改善。随后其精神运动发育稳定。
