在出生时用淋巴细胞使其产生耐受性的小鼠身上，与皮肤同种异体抗原不相容的皮肤移植片的行为。
The behavior of skin grafts incompatible with respect to skin alloantigens on mice rendered tolerant at birth with lymphoid cells.
作者信息
Silvers W K, Wachtel S S, Poole T W
出版信息
J Exp Med. 1976 Jun 1;143(6):1317-26. doi: 10.1084/jem.143.6.1317.
Abstract
It has been reported that lethally irradiated adult B6 mice restored with (A X B6) hemopoietic cells subsequently reject adult A-strain skin grafts because they are not tolerant of A-strain skin-specific (Sk) antigens. This thesis has been confirmed by a series of experiments conducted on neonatally treated animals. Thus sublethally irradiated neonatal B6 mice, inoculated with (A X B6) lymphoid cells, permanently accept these cells while subsequently rejecting adult strain A skin grafts. Further evidence that the destruction of these grafts results from the reaction of the host to Sk antigens, is provided by the fact that similarly treated recipients often permanently accept neonatal A-strain skin. Such grafts usually induce tolerance of adult A-strain skin grafts.
摘要
据报道，用（A×B6）造血细胞重建的经致死剂量照射的成年B6小鼠，随后会排斥成年A品系皮肤移植，因为它们对A品系皮肤特异性（Sk）抗原不耐受。这一论点已通过对新生期处理动物进行的一系列实验得到证实。因此，经亚致死剂量照射的新生B6小鼠接种（A×B6）淋巴细胞后，会永久接受这些细胞，随后排斥成年A品系皮肤移植。同样处理的受体通常会永久接受新生A品系皮肤，这一事实进一步证明了这些移植的破坏是宿主对Sk抗原反应的结果。此类移植通常会诱导对成年A品系皮肤移植的耐受性。
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