Lauriero F, Rubini G, D'Addabbo F, Rubini D, Schettini F, D'Addabbo A
Centro Interdipartimentale di Biocibernetica e Tecniche Radioisotopiche, Università di Bari, Italy.
Clin Nucl Med. 1995 Mar;20(3):243-9. doi: 10.1097/00003072-199503000-00011.
An account is given of the results observed with I-131 MIBG scintigraphy in four patients (1 bladder pheochromocytoma, 3 neuroblastomas) chosen on account of their particular clinical and diagnostic interest from a series of 41 apudoma patients examined by means of this technique. In the first patient, the unusual site of the tumor in the posterior wall of the bladder meant that its detection by I-131 MIBG was only possible after catheterization of the bladder. In the second patient, uptake in the metastasis was only evident after removal of the primary tumor. In the third patient, the scintiscan revealed several metastases (some in bone) not detected by CT. In the fourth patient (congenital neuroblastoma), enhanced uptake accompanied the appearance of high plasma catecholamine and urinary vanillylhandelic acid values, suggesting a functional switch from a nonsecreting to a secreting form. a supplementary In-111 DTPA-Octreotide (OCT) scintiscan of this patient demonstrated the presence of somatostatin receptors on the neuroblasts. Thus, this examination would seem particularly useful for the differentiation of nonsecreting neuroblastomas. Its employment in assessment of the therapeutic capacity of OCT itself is also suggested.
本文报告了4例患者（1例膀胱嗜铬细胞瘤，3例神经母细胞瘤）经I-131 MIBG闪烁扫描的观察结果。这4例患者是从41例经该技术检查的APUD瘤患者中挑选出来的，因其具有特殊的临床和诊断意义。在第1例患者中，肿瘤位于膀胱后壁这一不寻常部位，意味着只有在膀胱插管后才能通过I-131 MIBG检测到它。在第2例患者中，只有在切除原发肿瘤后转移灶的摄取才明显。在第3例患者中，闪烁扫描显示了一些CT未检测到的转移灶（一些在骨骼中）。在第4例患者（先天性神经母细胞瘤）中，高血浆儿茶酚胺和尿香草扁桃酸值出现时伴有摄取增强，提示从无分泌型向分泌型的功能转变。对该患者进行的补充性In-111 DTPA-奥曲肽（OCT）闪烁扫描显示神经母细胞上存在生长抑素受体。因此，这项检查似乎对无分泌型神经母细胞瘤的鉴别特别有用。还建议将其用于评估OCT本身的治疗能力。
