Ehrlich H P
Abteilungen für Chirurgie und Biochemie, Milton S. Hershey Medical Center, Pennsylvania State University College of Medicine, USA.
Chirurg. 1995 Mar;66(3):165-73.
The recovery from trauma is a function of life and survival of the organicism. Tissue injury resulting in irreversible cell death and connective tissue disruption initiates the repair process. Wounds heal by scarring where a new cell population resides in a newly deposited connective tissue matrix. The chemical composition of a scar is similar to normal dermis, but its organization differs from dermis. The ineptitude to reassemble collagen into normal dermal patterns specifics a scar. A scar patches a defect and in most cases normal function is restored. However with impaired scarring wound dehiscence occurs and the over production and deposition of unstable scar also causes a catastrophic end point. Besides the volume of scar tissue deposited, the organization of that tissue is important for determining the scar's integrity, stability and restoration of function. The maturation of scar dependents upon the character of the resident cell populations, quality of deposited connective tissue and the interactions between those components. Here our focus will be on the regulation of wound healing in terms of collagen fibers reorganization. As our knowledge of cell-cell and cell-matrix interactions in the repair process grows, the better the wound care offered to the patient in the future. The goal is to instigate and maintain a healing process where the pattern of deposited collagen fibers resembles that of dermis.
创伤后的恢复是机体生命与存活的一种机能。导致不可逆细胞死亡和结缔组织破坏的组织损伤启动修复过程。伤口通过瘢痕愈合，新的细胞群体存在于新沉积的结缔组织基质中。瘢痕的化学成分与正常真皮相似，但其组织结构与真皮不同。无法将胶原蛋白重新组装成正常真皮模式是瘢痕的特征。瘢痕填补缺损，在大多数情况下功能得以恢复正常。然而，瘢痕形成受损会导致伤口裂开，不稳定瘢痕的过度产生和沉积也会导致灾难性结局。除了沉积的瘢痕组织量外，该组织的结构对于确定瘢痕的完整性、稳定性和功能恢复也很重要。瘢痕的成熟取决于驻留细胞群体的特性、沉积结缔组织的质量以及这些成分之间的相互作用。在这里，我们将重点关注胶原纤维重组方面的伤口愈合调节。随着我们对修复过程中细胞 - 细胞和细胞 - 基质相互作用的了解不断增加，未来为患者提供的伤口护理将会更好。目标是促进并维持一个愈合过程，使沉积的胶原纤维模式类似于真皮。
