Husain S, Hadi S M
Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, India.
FEBS Lett. 1995 May 1;364(1):75-8. doi: 10.1016/0014-5793(95)00365-g.
It has been recently reported that L-DOPA and Cu(II) in the presence of H2O2 leads to extensive DNA damage. In this paper we show that L-DOPA in the presence of Cu(II) alone can cause DNA cleavage through the generation of reactive oxygen species such as the hydroxyl radical. Fluorescence quenching studies indicate that L-DOPA is capable of binding to DNA.
