Mizutani T, Nishiyama S, Amakawa I, Watanabe A, Nakamuro K, Terada N
Department of Obstetrics and Gynecology, Osaka Prefectural Hospital, Japan.
Fertil Steril. 1995 Jun;63(6):1184-9. doi: 10.1016/s0015-0282(16)57594-3.
To determine danazol concentrations in the ovary, uterus, and serum during daily vaginal administration of a danazol suppository and to examine its effect on the hypothalamic-pituitary-ovarian axis.
Sampling of tissues after vaginal or oral administration of danazol and sampling of blood during control and danazol-administration menstrual cycles.
Outpatient volunteers and inpatients at a public hospital.
Thirty patients who were to undergo hysterectomy and oophorectomy because of uterine leiomyoma and eight regularly menstruating volunteers.
Danazol was administered as a vaginal suppository (100 mg) or orally (400 mg).
Danazol concentrations in the ovary, uterus, and serum, and serum E2 and P levels.
Danazol concentrations in the ovary and uterus after daily vaginal administration of a suppository containing 100 mg danazol were comparable to those after daily oral administration of 400 mg danazol, but the serum danazol concentration was much lower. Menstrual cycle patterns of serum E2 and P levels were normal during daily vaginal administration of a danazol suppository.
Daily administration of a suppository containing 100 mg danazol produces high ovarian and uterine concentrations but low serum concentrations, and no effect was detected on the hypothalamic-pituitary-ovarian axis.
测定达那唑栓每日经阴道给药期间卵巢、子宫及血清中的达那唑浓度，并研究其对下丘脑 - 垂体 - 卵巢轴的影响。
经阴道或口服达那唑后组织取样，以及在对照和达那唑给药月经周期期间采血取样。
一家公立医院的门诊志愿者和住院患者。
30例因子宫平滑肌瘤计划接受子宫切除术和卵巢切除术的患者以及8名月经规律的志愿者。
达那唑以阴道栓剂（100毫克）或口服（400毫克）形式给药。
卵巢、子宫及血清中的达那唑浓度，以及血清E2和P水平。
每日经阴道给予含100毫克达那唑的栓剂后，卵巢和子宫中的达那唑浓度与每日口服400毫克达那唑后的浓度相当，但血清达那唑浓度低得多。在每日经阴道给予达那唑栓期间，血清E2和P水平的月经周期模式正常。
每日给予含100毫克达那唑的栓剂可使卵巢和子宫达到高浓度，但血清浓度低，且未检测到对下丘脑 - 垂体 - 卵巢轴有影响。
