Copperman A B, Horowitz G M, Kaplan P, Scott R T, Navot D, Hofmann G E
Mount Sinai School of Medicine, New York, New York, USA.
Fertil Steril. 1995 Jun;63(6):1267-71. doi: 10.1016/s0015-0282(16)57609-2.
To determine if premature luteinization (serum P levels > 1.1 ng/mL on or before the day of hCG administration) during controlled ovarian hyperstimulation (COH) is associated with elevated levels of serum hCG.
Tertiary fertility center.
Retrospective evaluation of ovum donors undergoing COH.
Forty-four women underwent COH. Comparisons of serum hCG levels and hormonal and cycle characteristics were made between cycles with premature luteinization (group I) and without premature luteinization (group II).
Group I (16 women) were similar to women in group II in age, amount of hMG, and the ratio of FSH:hMG received. Both groups received hCG on similar days, but women in group I had higher peak E2 levels. Serum hCG levels increased and correlated with serum P levels in group I only and were higher on the day of hCG administration (group I 1.8 +/- 0.9 mIU/mL versus group II 1.2 +/- 0.45 mIU/mL; conversion factor to SI unit, 1.00). Peak E2 and LH levels, ampules of hMG and the FSH:LH ratio, and day of hCG administration did not correlate with hCG levels. Human chorionic gonadotropin exposure, as measured by area under the curve, was significantly higher in group I compared with group II.
Higher serum levels of hCG and integrated hCG exposure are found in COH cycles with premature luteinization compared with cycles without premature luteinization. Higher hCG levels may be due to decreased clearance of hCG from the circulation and/or the hCG content of hMG.
确定在控制性卵巢刺激（COH）过程中过早黄素化（在注射人绒毛膜促性腺激素[hCG]当天或之前血清孕酮[P]水平>1.1 ng/mL）是否与血清hCG水平升高有关。
三级生殖中心。
对接受COH的卵子捐赠者进行回顾性评估。
44名女性接受了COH。对过早黄素化周期（I组）和未过早黄素化周期（II组）的血清hCG水平以及激素和周期特征进行了比较。
I组（16名女性）在年龄、人绝经促性腺激素（hMG）用量以及接受的促卵泡激素（FSH）与hMG比例方面与II组女性相似。两组在相似的日期接受hCG，但I组女性的雌二醇（E2）峰值水平更高。仅在I组中，血清hCG水平升高且与血清P水平相关，并且在注射hCG当天更高（I组1.8±0.9 mIU/mL，II组1.2±0.45 mIU/mL；转换为国际单位制的换算因子为1.00）。E2和促黄体生成素（LH）峰值水平、hMG安瓿数以及FSH与LH比例，以及注射hCG的日期与hCG水平均无相关性。通过曲线下面积测量的hCG暴露量，I组显著高于II组。
与未过早黄素化的周期相比，过早黄素化的COH周期中血清hCG水平和累积hCG暴露量更高。更高的hCG水平可能是由于hCG从循环中的清除减少和/或hMG中的hCG含量所致。
