Baty V, Denis B, Goudot C, Bas V, Renkes P, Bigard M A, Boissel P, Gaucher P
Service d'Hépato-Gastroentérologie, CHU Nancy-Brabois, Vandoeuvre-les-Nancy.
Gastroenterol Clin Biol. 1994;18(12):1129-31.
Acute hepatitis related to psychotropic drugs has been rarely reported with anxiolytic treatments. Alpidem (Ananxyl) is a new imidazopyridine derivative with anxiolytic properties which was launched in October 1991. Several cases of acute hepatitis, some severe, were described with this drug and its liver toxicity was questioned. Results of a study monitoring drug side-effects caused this drug to be withdrawn from the market for one year. We report four cases of acute hepatitis and discuss the role of alpidem. All but one case were presented as severe acute hepatitis with hepatic failure. One patient ran a fulminant course and died despite liver transplantation. The mechanism of liver toxicity remains unclear.
与精神药物相关的急性肝炎在抗焦虑治疗中鲜有报道。阿吡坦（安奈西泮）是一种具有抗焦虑特性的新型咪唑并吡啶衍生物，于1991年10月上市。有几例使用该药物后出现急性肝炎的病例，其中一些较为严重，其肝毒性受到质疑。一项监测药物副作用的研究结果导致该药物从市场上撤下一年。我们报告了4例急性肝炎病例，并讨论了阿吡坦的作用。除1例病例外，其余均表现为伴有肝衰竭的严重急性肝炎。1例患者病情呈暴发性发展，尽管进行了肝移植仍死亡。肝毒性机制尚不清楚。
