Demarin V, Rundek T, Podobnik-Sarkanji S, Lovrencic-Huzjan A
Department of Neurology, University Hospital Sestre Milosrdnice, Zagreb, Croatia.
Funct Neurol. 1994 Sep-Oct;9(5):235-45.
Cerebral haemodynamics and the level of serum 5-hydroxytriptamine (5-HT) were analysed in 21 migraine patients (8 with and 13 without aura) during the headache-free period as well as the attack. Cerebral vasoreactivity was evaluated by acetazolamide test and Transcranial Doppler ultrasonography (TCD). TCD findings were within normal ranges in the majority of migraine patients. Patients with migraine without aura had higher blood flow velocities (BFV) than patients with aura. Comparison of BVF and pulsatility index (PI) data patterns in migraine with and in migraine without aura during the attack revealed differences indicating cerebral hypoperfusion. It was noticed that systolic BFV decreased in migraine with aura on the headache side while PI increased. In migraine without aura, both systolic BFV and PI increased. 5-HT findings were heterogeneous. Reduction of cerebral vasoreactivity was observed especially in migraine with aura. Our results suggest different pathogenic mechanisms between migraine with and without aura, supporting the neurogenic inflammation theory.
对21例偏头痛患者（8例有先兆，13例无先兆）在头痛缓解期及发作期的脑血流动力学和血清5-羟色胺（5-HT）水平进行了分析。通过乙酰唑胺试验和经颅多普勒超声（TCD）评估脑血管反应性。大多数偏头痛患者的TCD检查结果在正常范围内。无先兆偏头痛患者的血流速度（BFV）高于有先兆患者。比较发作期有先兆偏头痛和无先兆偏头痛患者的BFV和搏动指数（PI）数据模式发现，存在表明脑灌注不足的差异。注意到有先兆偏头痛患者头痛侧的收缩期BFV降低，而PI升高。在无先兆偏头痛中，收缩期BFV和PI均升高。5-HT的结果存在异质性。尤其在有先兆偏头痛中观察到脑血管反应性降低。我们的数据提示有先兆和无先兆偏头痛之间存在不同的致病机制，支持神经源性炎症理论。
