Honjo H, Tanaka K, Kashiwagi T, Urabe M, Okada H, Hayashi M, Hayashi K
Department of Obstetrics and Gynecology, Kyoto Prefectural University of Medicine, Japan.
Horm Metab Res. 1995 Apr;27(4):204-7. doi: 10.1055/s-2007-979941.
Some reports have suggested the ameliorative effects of estrogens on clinical symptoms, such as short memory, in women suffering from senile dementia-Alzheimer's type, in vivo. The action mechanism of estrogen remains to be clarified, but 1) an anti-depressive effect, 2) improvement of cerebral blood flow, 3) direct stimulation of neuron, 4) development of gliacyte and 5) suppression of apolipoprotein E have been suggested. Some mechanisms may be combined, contributing to the beneficial effects on clinical symptoms.
一些报告表明，雌激素对患有老年痴呆症（阿尔茨海默病类型）的女性的临床症状，如短期记忆，具有改善作用。雌激素的作用机制尚待阐明，但已提出以下几点：1）抗抑郁作用；2）改善脑血流量；3）直接刺激神经元；4）促进神经胶质细胞发育；5）抑制载脂蛋白E。某些机制可能相互结合，从而对临床症状产生有益影响。
