Tonetti M S, Pini-Prato G, Cortellini P
Department of Periodontology and Fixed Prosthodontics, University of Bern, Switzerland.
Int J Periodontics Restorative Dent. 1994 Oct;14(5):421-35.
Controlled drug delivery of antibiotics in the periodontal pocket is a scientifically tested clinical reality. Application of pharmacokinetic principles allows effective suppression of the pathogenic microflora, which, in turn, results in resolution of inflammatory signs. In the cases presented, tetracycline fibers were employed as a supplement to mechanical therapy and oral hygiene in a variety of clinical situations. Outcomes included depression of periodontal pathogens, reduction of bleeding on probing, decrease in probing pocket depths, and increase in probing attachment levels. A novel therapeutic approach based on root planing for debridement, local drug delivery for control of the pathogens, and oral hygiene for preventing recolonization is discussed.
在牙周袋中进行抗生素的控释给药是经过科学验证的临床实际应用。药代动力学原理的应用能够有效抑制致病微生物群落，进而使炎症体征消退。在本文所呈现的病例中，四环素纤维被用作多种临床情况下机械治疗和口腔卫生措施的补充。治疗结果包括牙周病原菌数量减少、探诊出血减少、探诊牙周袋深度降低以及探诊附着水平增加。本文还讨论了一种基于根面平整进行清创、局部给药控制病原菌以及保持口腔卫生以防止再定植的新型治疗方法。
