Badalian K, Der-Sarkissian M, Sabetzadeh H
J Trop Med Hyg. 1976 Feb;79(2):28-31.
According to the procedure of Cordano (1971), the identification of biotypes of 118 strains of Salmonella typhimurium isolated from stools or rectal swabs of patients with sporadic cases of diarrhoea on the Central Plateau during the period 1962-1973 revealed that: From 118 S. typhimurium, 65 (55-1%) were biotype "d", 50 (42-4%) were "a" and three (2-5%) were "b". The predominant biotype was "d", followed by the "a" biotype, and "b" was rarely encountered. Biotype "d" has existed since 1965, and after that date has increased. Biotype "a" existed from the beginning of the study, but has decreased during the period 1962-1973. Sensitivity tests were performed according to Bauer (1966). Biotypes "d" and "a" showed a high degree of resistance to tetracycline, chloramphenicol, streptomycin, triple-sulfa, ampicillin, furazolidone, kanamycin, neomycin, paromomycin, cephalothin and co-trimoxazole. All isolated biotypes "d" were multiple drug-resistant, while some of the strains of biotype "a" were resistant and some sensitive. All three biotypes "b" were sensitive to all drugs examined. Resistance to drugs for biotypes "d" and "a" increased with time. The predominant pattern of resistance for all biotypes was found to be resistance to eight drugs: tetracycline, chloramphenicol, streptomycin, triple-sulfa, ampicillin, kanamycin, neomycin and paromomycin (Tc, Cm, Sm, Su, Am, K, N, Par). Considering the relationship between resistance pattern and biotypes, the predominant pattern in biotype "d" was resistance to eight drugs (Tc, Cm, Sm, Su, Am, K, N, Par) (47-7%), and in biotype "a" was resistance to nine drugs, tetracycline, chloramphenicol, streptomycin, triple-sulfa, ampicillin, furazolidone, kanamycin, neomycin, paromomycin (Tc, Cm, Sm, Su, Am, Fx, K, N, Par) (28%).
根据科尔达诺（1971年）的方法，对1962年至1973年期间从中央高原散发性腹泻患者的粪便或直肠拭子中分离出的118株鼠伤寒沙门氏菌的生物型进行鉴定，结果显示：在118株鼠伤寒沙门氏菌中，65株（55.1%）为生物型“d”，50株（42.4%）为“a”，3株（2.5%）为“b”。主要生物型为“d”，其次是“a”生物型，“b”型很少见。生物型“d”自1965年以来就已存在，此后数量有所增加。生物型“a”从研究开始就存在，但在1962年至1973年期间数量减少。根据鲍尔（1966年）的方法进行了药敏试验。生物型“d”和“a”对四环素、氯霉素、链霉素、三联磺胺、氨苄青霉素、呋喃唑酮、卡那霉素、新霉素、巴龙霉素、头孢噻吩和复方新诺明表现出高度耐药性。所有分离出的生物型“d”均为多重耐药，而生物型“a”的一些菌株耐药，一些敏感。所有三株生物型“b”对所有检测药物均敏感。生物型“d”和“a”对药物的耐药性随时间增加。所有生物型的主要耐药模式为对八种药物耐药：四环素、氯霉素、链霉素、三联磺胺、氨苄青霉素、卡那霉素、新霉素和巴龙霉素（Tc、Cm、Sm、Su、Am、K、N、Par）。考虑到耐药模式与生物型之间的关系，生物型“d”的主要耐药模式为对八种药物耐药（Tc、Cm、Sm、Su、Am、K、N、Par）（47.7%），生物型“a”的主要耐药模式为对九种药物耐药，即四环素、氯霉素、链霉素、三联磺胺、氨苄青霉素、呋喃唑酮、卡那霉素、新霉素、巴龙霉素（Tc、Cm、Sm、Su、Am、Fx、K、N、Par）（28%）。
