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脊髓灰质炎与有用知识的来源

Poliomyelitis and the sources of useful knowledge.

作者信息

Bodian D

出版信息

Johns Hopkins Med J. 1976 Apr;138(4):130-36.

PMID:775168
Abstract

Dr. Richard Ross during his introduction observed that Dr. Bodian made three contributions to the study of poliomyelitis which laid the groundwork essential to the ultimate triumph over the disease by immunization. The first was the identification of three types of poliovirus. This was absolutely basic to the development of a vaccine. The second was the identification of the viremia which occurred before the paralysis began and thus, indicated how it would be possible for an immune response to be effective. The third important contribution was the demonstration that immunity could be developed in primates with very low antibody levels.

摘要

理查德·罗斯博士在介绍过程中指出,博迪安博士对脊髓灰质炎研究做出了三项贡献,这些贡献为最终通过免疫战胜该疾病奠定了至关重要的基础。第一项贡献是确定了三种脊髓灰质炎病毒类型。这对于疫苗的研发绝对是基础性的。第二项贡献是确定了在瘫痪开始前出现的病毒血症,从而表明免疫反应如何能够有效。第三项重要贡献是证明了在抗体水平非常低的灵长类动物中也能产生免疫力。

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