Frith C H, Highman B, Konvicka A J
Lab Anim Sci. 1976 Apr;26(2 Pt l):171-85.
The establishment of the National Center for Toxicological Research (NCTR), Jefferson, AR, to study long term effects of low doses of potentially toxic substances, including carcinogens, resulted in the initiation of chronic experiments requiring histophatologic studies of large numbers of animals. Processing the tissues and recording and analyzing the massive amount of pathologic data from these studies required innovative automated technics. The result was a unique computerized pathology data system of NCTR. The system encompasses the development of training programs for necropsy techincians, histology technicians, and pathology tissue screeners; the use of automated equipment for processing, embedding, sectioning, and staining tissue; the use of prelabeled cassettes, slides, and pathology forms; the use of mark-sensitive forms for the collection of gross and microscopic findings; the use of data collection terminals for animal identification, animal weights, and organ weights; the collection of gross and microscopic data on a Mod Comp III minicomputer; and the storage, analysis, and generation of pathology reports and tables over a data link from an IBM 370-158 computer. Some of the features of this system may be applicable in other toxicology laboratories and medical pathology departments.
位于阿肯色州杰斐逊市的国家毒理学研究中心（NCTR）的设立，旨在研究低剂量潜在有毒物质（包括致癌物）的长期影响，这导致了需要对大量动物进行组织病理学研究的慢性实验的启动。处理这些研究中的组织以及记录和分析大量病理数据需要创新的自动化技术。结果是形成了NCTR独特的计算机化病理数据系统。该系统包括为尸检技术员、组织学技术员和病理组织筛查员开发培训项目；使用自动化设备对组织进行处理、包埋、切片和染色；使用预先标记的盒式标本、载玻片和病理表格；使用标记敏感表格收集大体和显微镜检查结果；使用数据收集终端记录动物标识、动物体重和器官重量；在Mod Comp III小型计算机上收集大体和显微镜数据；以及通过IBM 370 - 158计算机的数据链路存储、分析并生成病理报告和表格。该系统的一些特性可能适用于其他毒理学实验室和医学病理科。
