Uziel Y, Laxer R M, Blaser S, Andrew M, Schneider R, Silverman E D
Department of Pediatrics, Hospital for Sick Children, Toronto, Canada.
J Pediatr. 1995 May;126(5 Pt 1):722-7. doi: 10.1016/s0022-3476(95)70399-3.
We describe three cases of cerebral vein thrombosis (CVT) in girls with systemic lupus erythematosus. Severe, persistent, unremitting headache was a common manifestation. In the first patient, although the clinical features were suggestive of CVT, the diagnosis was delayed and she had a significant cerebral infarct. In the other two patients the diagnosis was made earlier and led to more rapid treatment; the institution of early therapy may have prevented further sequelae. The CVT was diagnosed in all patients with a combination of computed tomography and magnetic resonance imaging studies without the need for angiography. All patients were treated for their underlying systemic lupus erythematosus and with anticoagulation. All are receiving long-term low doses of warfarin and have not had any recurrences.
我们描述了3例患有系统性红斑狼疮的女孩发生脑静脉血栓形成（CVT）的病例。严重、持续、不间断的头痛是常见表现。在首例患者中，尽管临床特征提示为CVT，但诊断被延误，她发生了严重的脑梗死。在另外两名患者中，诊断较早并得以更迅速地治疗；早期治疗的实施可能预防了进一步的后遗症。所有患者均通过计算机断层扫描和磁共振成像检查相结合确诊为CVT，无需进行血管造影。所有患者均针对其潜在的系统性红斑狼疮进行了治疗并接受了抗凝治疗。所有患者均接受长期小剂量华法林治疗，且未出现任何复发情况。
