Serni U, Fibbi G, Anichini E, Zamperini A, Pucci M, Mannoni A, Matucci A, Benucci M, Del Rosso A, Del Rosso M
Institute of General Pathology, Florence University, Italy.
J Rheumatol Suppl. 1995 Feb;43:120-2.
Evidence indicates that breakdown of articular cartilage resulting in the loss of normal joint function is the distinctive feature of osteoarthritis. Degradation of cartilage extracellular matrix components involves the action of at least 2 classes of proteinases: serine proteinases and metalloproteinases. Receptors have been described on a wide range of cell lines for many such proteinases [urokinase-type plasminogen activator (u-PA), plasminogen/plasmin, collagenase], which subsequently activate each other on the solid phase of the cell surface, leading to cartilage destruction. We review the leading role of u-PA and its receptor (u-PAR) in cartilage degradation.
有证据表明，导致正常关节功能丧失的关节软骨破坏是骨关节炎的显著特征。软骨细胞外基质成分的降解涉及至少两类蛋白酶的作用：丝氨酸蛋白酶和金属蛋白酶。许多这类蛋白酶[尿激酶型纤溶酶原激活剂（u-PA）、纤溶酶原/纤溶酶、胶原酶]在多种细胞系上都有受体，这些受体随后在细胞表面的固相上相互激活，导致软骨破坏。我们综述了u-PA及其受体（u-PAR）在软骨降解中的主导作用。
