Shinmei M, Kobayashi T, Yoshihara Y, Samura A
Department of Orthopedic Surgery, National Defense Medical College, Saitama, Japan.
J Rheumatol Suppl. 1995 Feb;43:78-81.
The joint fluid levels of several molecules that reflect the anabolism and catabolism of cartilage matrix and its inflammation were quantitated in patients with primary osteoarthritis (OA) and traumatic arthritis. The carboxy terminal type II procollagen increased in primary OA and traumatic arthritis joint fluid and was thought to be a good marker of the repair response of chondrocytes. We found that the increase of this molecule in the joint correlated well with body mass index in primary OA and the degree of cartilage erosion caused by joint instability in traumatic arthritis. Chondroitin 6-sulfate, an integral part of human aggrecan, was also high in OA and traumatic arthritis joint fluids, and showed a similar distribution with keratan sulfate in each disease group. Stromelysin-1 and tissue inhibitor of metalloproteinases-1 levels in joint fluid were very high in RA, but levels in patients with OA were low. Carboxy terminal type II procollagen appeared most sensitive in the evaluation of risk factors of OA such as obesity and joint instability, compared to other markers tested.
在原发性骨关节炎（OA）和创伤性关节炎患者中，对几种反映软骨基质合成代谢、分解代谢及其炎症的分子的关节液水平进行了定量分析。羧基末端II型前胶原在原发性OA和创伤性关节炎关节液中升高，被认为是软骨细胞修复反应的良好标志物。我们发现，该分子在关节中的升高与原发性OA中的体重指数以及创伤性关节炎中关节不稳定导致的软骨侵蚀程度密切相关。硫酸软骨素6-硫酸盐是人类聚集蛋白聚糖的一个组成部分，在OA和创伤性关节炎关节液中也很高，并且在每个疾病组中与硫酸角质素表现出相似的分布。基质金属蛋白酶-1和金属蛋白酶组织抑制剂-1在类风湿关节炎（RA）患者关节液中的水平非常高，但OA患者的水平较低。与其他测试标志物相比，羧基末端II型前胶原在评估OA的危险因素如肥胖和关节不稳定方面似乎最敏感。
