Nørgaard J P, Jønler M, Rittig S, Djurhuus J C
Urological Department K, Aarhus University Hospital, Skejby Section, Denmark.
J Urol. 1995 Jun;153(6):1984-6.
The pharmacokinetics of desmopressin (1-desamino-8-D-arginine vasopressin) were investigated in 8 patients with nocturnal enuresis, of whom 4 were known to respond completely to desmopressin and 4 were nonresponders. A decrease in urine production was confirmed in responders after the administration of desmopressin while the drug did not cause antidiuresis in nonresponders. Absorption and excretion of desmopressin were identical in each group. Results indicate at least 2 pathophysiological mechanisms in nocturnal enuresis, including insufficient nocturnal production of arginine vasopressin and impaired renal sensitivity to arginine vasopressin and desmopressin. Each type results in high nocturnal urine production.
对8例夜间遗尿症患者进行了去氨加压素（1-去氨基-8-D-精氨酸加压素）的药代动力学研究，其中4例已知对去氨加压素完全有反应，4例无反应。给予去氨加压素后，有反应者的尿量减少得到证实，而该药物在无反应者中未引起抗利尿作用。每组中去氨加压素的吸收和排泄情况相同。结果表明夜间遗尿症至少有2种病理生理机制，包括夜间精氨酸加压素分泌不足以及肾脏对精氨酸加压素和去氨加压素的敏感性受损。每种类型都会导致夜间尿量增多。
