Tammela T L, Leggett R E, Levin R M, Longhurst P A
Division of Urology, University of Pennsylvania, Philadelphia, USA.
J Urol. 1995 Jun;153(6):2014-21.
Studies were done to compare the acute effects of streptozotocin-induced diabetes and sucrose consumption on micturition, bladder mass and contractile responses of bladder strips to field stimulation and contractile agonists. Micturition changes occurred gradually in diabetic rats, reached maximal values within 7 to 14 days, and were accompanied by significant increases in bladder mass after 7 days. Bladder strips from diabetics responded to field stimulation, carbachol and KCl with significantly greater contractions than did those from controls within 7 days. Sucrose-drinking rats had maximal increases in fluid consumption and micturition frequency on the first night after starting treatment. Increases in micturition volumes were slower to develop than in diabetics. Bladder mass was significantly increased 30 and 60 days after starting sucrose treatment. Bladder strips from sucrose-drinking rats responded to field stimulation and carbachol with significantly greater contractions than did those from controls only after 60 days. Monitoring of drinking and micturition patterns established that diabetic rats drink and urinate during both the dark and light cycles. In contrast, control and sucrose-drinking rats drink and urinate principally at night. The results demonstrate that differences in bladder function between diabetic and sucrose drinking rats are apparent during the first month after treatment begins. The data suggest that the effects of diabetes and sucrose consumption on contractile bladder function are related to the diuresis-induced increases in bladder mass.
开展了多项研究，以比较链脲佐菌素诱导的糖尿病和蔗糖摄入对排尿、膀胱质量以及膀胱条带对场刺激和收缩激动剂的收缩反应的急性影响。糖尿病大鼠的排尿变化是逐渐发生的，在7至14天内达到最大值，且7天后膀胱质量显著增加。糖尿病大鼠的膀胱条带在7天内对场刺激、卡巴胆碱和氯化钾的反应，其收缩程度显著大于对照组。饮用蔗糖的大鼠在开始治疗后的第一个晚上，液体摄入量和排尿频率最大幅度增加。排尿量的增加比糖尿病大鼠发展得更慢。开始蔗糖治疗30天和60天后，膀胱质量显著增加。饮用蔗糖的大鼠的膀胱条带仅在60天后对场刺激和卡巴胆碱的反应，其收缩程度显著大于对照组。对饮水和排尿模式的监测表明，糖尿病大鼠在明暗周期都会饮水和排尿。相比之下，对照组和饮用蔗糖的大鼠主要在夜间饮水和排尿。结果表明，糖尿病大鼠和饮用蔗糖的大鼠在治疗开始后的第一个月内，膀胱功能的差异就很明显。数据表明，糖尿病和蔗糖摄入对膀胱收缩功能的影响与利尿诱导的膀胱质量增加有关。
