Henly D R, Barrett D M, Weiland T L, O'Connor M K, Malizia A A, Wein A J
Department of Urology, Mayo Clinic, Rochester, Minnesota 55905, USA.
J Urol. 1995 Jun;153(6):2039-43.
We examined the histologic behavior and migratory tendencies of a silicone-based injectable paste (Macroplastique) with potential application in treating urinary incontinence. Thirteen female dogs were studied. Six received 2 periurethral injections of large-particle paste, with a median diameter of 110 microns, and 7 received similar injections with small-particle paste (median diameter, 73 microns). The paste was radiolabeled with cobalt-57. Histologic analysis was performed at 4 or 9 months. The pathologic appearance revealed intact large-particle injection sites. The small-particle sites had dissipated significantly. This was confirmed by nuclear imaging. Large particles produced an encapsulated fibrous sheath without local migration. There was a histiocytic reaction within the injection site but no granuloma formation. Distant migration was observed in 1 dog (short term, large particle), without an inflammatory response. Migration of silicone occurred locally and distantly in animals that received small particles. X-ray microanalysis confirmed the presence of silicone particles.
我们研究了一种具有治疗尿失禁潜在应用价值的硅基注射性糊剂（Macroplastique）的组织学行为和迁移倾向。对13只雌性犬进行了研究。6只接受了2次尿道周围大颗粒糊剂注射，颗粒中位直径为110微米，7只接受了类似的小颗粒糊剂注射（中位直径73微米）。糊剂用钴-57进行放射性标记。在4个月或9个月时进行组织学分析。病理表现显示大颗粒注射部位完整。小颗粒部位已明显消散。核成像证实了这一点。大颗粒产生了一个被包裹的纤维鞘，无局部迁移。注射部位有组织细胞反应，但无肉芽肿形成。在1只犬中观察到远距离迁移（短期，大颗粒），无炎症反应。接受小颗粒的动物中，硅酮在局部和远处均发生迁移。X射线微量分析证实了硅酮颗粒的存在。
