Satoh S, Kaneko T, Omori S, Sugimura J, Ujiie T, Fujioka T, Kubo T
Department of Urology, Iwate Medical University, School of Medicine, Morioka, Japan.
Nihon Jinzo Gakkai Shi. 1995 Feb;37(2):112-8.
The effect of an angiotensin-converting enzyme inhibitor, enalapril, and a Japanese medicinal plant named sairei-to, after administration either alone or in combination, on survival-time due to the protection of proteinuria and the preserving of renal function, was studied in the rat with subtotal nephrectomy. Resection of 2/3 of the left kidney and removal of the right kidney was performed in 28 male Wister rats (220-250 g). The rats were divided into four groups: (1) control (without sairei-to or enalapril); (2) with sairei-to (2.5% in rat chow); (3) with enalapril (50 mg/l in drinking water); and (4) the combination of enalapril and sairei-to. The actual survival-times until natural death after renal ablation in these four groups were 92 +/- 3, 128 +/- 8, 199 +/- 19, and 194 +/- 13 days, respectively. Urinary protein excretion and renal function were markedly protected in the enalapril-treated rats. Urinary endothelin excretion was also attenuated in enalapril-treated rats. Statistical analysis revealed the absence of benefits with sairei-to alone or in combination treatment. In conclusion, enalapril provides protection of proteinuria and preserves renal function, which results in a longer survival-time in the rats having subtotal nephrectomy. However, sairei-to does not show such beneficial effects.
在大鼠肾次全切除模型中，研究了血管紧张素转换酶抑制剂依那普利和一种名为柴苓汤的日本药用植物单独或联合给药后，对蛋白尿的保护作用及肾功能的维持作用对生存时间的影响。选取28只雄性Wistar大鼠（体重220 - 250克），切除左肾的2/3并摘除右肾。将大鼠分为四组：（1）对照组（未给予柴苓汤或依那普利）；（2）给予柴苓汤组（大鼠饲料中含2.5%柴苓汤）；（3）给予依那普利组（饮用水中含50毫克/升依那普利）；（4）依那普利与柴苓汤联合组。这四组大鼠肾切除后至自然死亡的实际生存时间分别为92±3天、128±8天、199±19天和194±13天。依那普利治疗的大鼠尿蛋白排泄和肾功能得到显著保护。依那普利治疗的大鼠尿内皮素排泄也有所减少。统计分析显示，单独使用柴苓汤或联合治疗均无益处。总之，依那普利可保护蛋白尿并维持肾功能，从而使肾次全切除大鼠的生存时间延长。然而，柴苓汤未显示出此类有益效果。
