Bonnefoi-Kyriacou B, Trouche E, Legallet E, Viallet F
Service de Neurologie, CHG Aix-en-Provence, France.
Mov Disord. 1995 Mar;10(2):171-8. doi: 10.1002/mds.870100207.
Twelve patients with cerebellar dysfunction including a limb ataxia and 12 age-matched controls performed pointing movements with an arm. In one condition, the task was a simple reaction time (RT) movement directed toward a spatially defined target. The other two conditions involved choice tasks in which the amplitude and direction of movement were varied. The variables recorded were: movement latency determined by measuring the RT, duration of movement and the terminal accuracy of pointing as reflected in the movement time (MT), pointing surfaces (PS), and systematic errors. RTs and MTs were found to be significantly longer in cerebellar patients than in controls. In both groups the choice RT increased significantly as compared to simple RT, but no significant difference between patients and controls was found for the mean increase of the choice RT as compared with the mean increase for simple RT. A strong correlation between MTs and PSs was found in the controls. The cerebellar patients showed no correlation between MTs and PSs. The results are discussed in relation to the ability in cerebellar patients to program and execute voluntary movements.
12名患有小脑功能障碍（包括肢体共济失调）的患者和12名年龄匹配的对照组人员用手臂进行指向动作。在一种情况下，任务是朝着空间定义的目标进行简单反应时间（RT）动作。另外两种情况涉及选择任务，其中动作的幅度和方向有所变化。记录的变量包括：通过测量RT确定的动作潜伏期、动作持续时间以及指向的终端准确性，这通过动作时间（MT）、指向表面（PS）和系统误差反映出来。发现小脑患者的RT和MT明显比对照组更长。在两组中，与简单RT相比，选择RT显著增加，但与简单RT的平均增加相比，患者和对照组在选择RT的平均增加方面没有显著差异。在对照组中发现MT和PS之间存在很强的相关性。小脑患者的MT和PS之间没有相关性。结合小脑患者编程和执行自主动作的能力对结果进行了讨论。
