Cardoso F, Jankovic J, Grossman R G, Hamilton W J
Department of Neurology, Baylor College of Medicine, Houston, Texas, USA.
Neurosurgery. 1995 Mar;36(3):501-7; discussion 507-8. doi: 10.1227/00006123-199503000-00009.
The outcome after single or staged stereotactic thalamotomies in 17 patients with dystonia and 2 patients with hemiballismus is reviewed. All patients were severely disabled by their movement disorders despite optimal pharmacological therapies. Eight of the patients with dystonia (47%) showed moderate improvement immediately after the procedures. Six of these eight patients maintained their improvement, and two other patients with dystonia improved significantly, during the follow-up period (mean, 37.6 mo). The long-term outcome was better in patients with secondary dystonia (50% moderately or markedly improved at a mean of 41.0 mo) than in patients with primary dystonia (43% moderately or markedly improved at a mean of 32.9 mo). Excellent control was achieved in both of the patients who underwent thalamotomies for hemiballismus.
回顾了17例肌张力障碍患者和2例偏侧舞蹈症患者单次或分期立体定向丘脑切开术的结果。尽管采用了最佳药物治疗，所有患者均因运动障碍而严重致残。8例肌张力障碍患者（47%）术后立即出现中度改善。这8例患者中有6例维持了改善效果，另外2例肌张力障碍患者在随访期间（平均37.6个月）有显著改善。继发性肌张力障碍患者的长期疗效（平均41.0个月时50%中度或明显改善）优于原发性肌张力障碍患者（平均32.9个月时43%中度或明显改善）。接受丘脑切开术治疗偏侧舞蹈症的2例患者均实现了良好控制。
