Bianco V, De Benedetto A, Simeoni F, Toto A, Paris E, Chiodini S, Marchei P
Dipartimento di Medicina Sperimentale, Università degli Studi di Roma La Sapienza.
Minerva Med. 1995 Jan-Feb;86(1-2):17-20.
The traditional prognostic factors (tumour size, lymph node involvement, receptor status) have now been shown to have limits in terms of prognostic definition. These limits may be partially overcome when parameters exist to determine the extent of tumour biological aggression and the patient's degree of immune response. It is important to clarify these links because they may lead to more precise indications regarding the prognosis and choice of therapy, above all in cases of breast cancer operated with no lymph node involvement. Breast carcinoma is often surrounded by inflammatory cells showing host and tumour interaction. The aim of this study was to evaluate the prognostic value of lymphocyte infiltration in operated breast cancer. The degree of lymphocyte infiltration observed in 56 breast cancer patients was compared with other prognostic factors (tumour size, lymph node status, histological variants, necrotic areas and desmoplastic reaction). This preliminary study allowed the authors to examine the degree of peritumoral lymphocyte density as an important predictive index of overall survival in patients with breast cancer and N-.
传统的预后因素（肿瘤大小、淋巴结受累情况、受体状态）现已表明在预后定义方面存在局限性。当存在用于确定肿瘤生物侵袭程度和患者免疫反应程度的参数时，这些局限性可能会得到部分克服。阐明这些联系很重要，因为它们可能会带来关于预后和治疗选择的更精确指征，尤其是在无淋巴结受累的乳腺癌手术病例中。乳腺癌通常被显示宿主与肿瘤相互作用的炎性细胞所包围。本研究的目的是评估手术治疗的乳腺癌中淋巴细胞浸润的预后价值。将56例乳腺癌患者中观察到的淋巴细胞浸润程度与其他预后因素（肿瘤大小、淋巴结状态、组织学变体、坏死区域和促纤维增生反应）进行比较。这项初步研究使作者能够将肿瘤周围淋巴细胞密度程度作为乳腺癌N-患者总生存的重要预测指标进行研究。
