苦木的抗生育活性：苦木素在体外抑制大鼠睾丸间质细胞的类固醇生成。
Antifertility activity of Quassia amara: quassin inhibits the steroidogenesis in rat Leydig cells in vitro.
作者信息
Njar V C, Alao T O, Okogun J I, Raji Y, Bolarinwa A F, Nduka E U
出版信息
Planta Med. 1995 Apr;61(2):180-2. doi: 10.1055/s-2006-958044.
PMID:7753928
Abstract
The crude methanol extract of the stem wood of Quassia amara L. inhibited both the basal and LH-stimulated testosterone secretion of rat Leydig cells in a dose-dependent fashion. Fractionation of the extract by chromatography gave quassin (1) and 2-methoxycanthin-6-one (2); compound 1 proved to be the bioactive agent.
摘要
苦木茎木的粗甲醇提取物以剂量依赖性方式抑制大鼠睾丸间质细胞的基础睾酮分泌和促黄体生成素刺激的睾酮分泌。通过色谱法对提取物进行分离得到苦木素（1）和2-甲氧基-6-酮基咔啉（2）；化合物1被证明是生物活性剂。
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