Vivaldi P, Comotti C, Prevedello C, Rovati C
UO Medicina 2a, Ospedale S. Chiara, Trento.
Recenti Prog Med. 1995 Feb;86(2):71-5.
The renal involvement in a multiple myeloma case (MM) has a frequency of 50% and causes a worsening of the disease with a survival average of about 12 months. Myeloma cast nephropathy (MCN) represents the more frequent clinic, histological form of nephropathy in course of MM and it evolves when monoclonal light free chain deposit in the renal tubules together with some other worse cases like dehydration and/or hypercalcaemia. We analyze here the clinical and renal histological features of eight patients treated for acute renal failure found in MCN in course of MM grade B. This was discovered through renal bioptic check-up. We have evaluated the Bence-Jones proteinuria, the recurrence of the condition of risk and the course of the renal failure of these patients also in order to treat the hematological illness.
多发性骨髓瘤（MM）病例中的肾脏受累发生率为50%，会导致疾病恶化，平均生存期约为12个月。骨髓瘤管型肾病（MCN）是MM病程中较常见的临床、组织学形式的肾病，当单克隆游离轻链与其他一些更严重的情况（如脱水和/或高钙血症）一起沉积在肾小管时就会发生。我们在此分析了8例因MM B级病程中MCN导致急性肾衰竭而接受治疗的患者的临床和肾脏组织学特征。这是通过肾脏活检检查发现的。我们还评估了这些患者的本周氏蛋白尿、风险状况的复发以及肾衰竭的病程，以便治疗血液系统疾病。
