Hikichi T, Konno S, Trempe C L
Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.
Retina. 1995;15(1):29-33. doi: 10.1097/00006982-199515010-00006.
The role of the vitreous in eyes with CRVO and its relationship to neovascularization and macular edema, in particular, were investigated.
A retrospective chart review of the vitreous condition of 136 patients (136 eyes) with CRVO was performed. Based on fluorescein angiography findings and color photographs, eyes with CRVO were classified as either ischemic or nonischemic.
In ischemic cases, retinal or optic disc neovascularization or both developed in 8 (57%) of 14 eyes with no or partial posterior vitreous detachment (PVD) at the final examination. The prevalence of neovascularization was significantly higher than in eyes with complete PVD (0%, 0 of 38) at the final examination (P < 0.01). No significant relationship was found between iris neovascularization development and the vitreous condition or between the prevalence of PVD and macular edema. In nonischemic eyes, the prevalence of no PVD or partial PVD with vitreomacular attachment was significantly higher in those with macular edema (76%, 25 of 33) than in eyes without (25%, 13 of 51) at the final examination (P < 0.01).
Complete PVD may protect against retinal or optic disc neovascularization in eyes with severe CRVO. Vitreomacular attachment may cause persistent macular edema in eyes with mild CRVO.
研究玻璃体在视网膜中央静脉阻塞（CRVO）眼中的作用及其与新生血管形成和黄斑水肿的关系，尤其是二者之间的关系。
对136例（136只眼）CRVO患者的玻璃体状况进行回顾性病历分析。根据荧光素血管造影结果和彩色照片，将CRVO眼分为缺血性或非缺血性。
在缺血性病例中，在最后检查时，14只无或部分玻璃体后脱离（PVD）的眼中有8只（57%）出现视网膜或视盘新生血管形成或两者皆有。最后检查时，新生血管形成的发生率显著高于完全PVD的眼（0%，38只眼中0只）（P<0.01）。未发现虹膜新生血管形成与玻璃体状况之间或PVD发生率与黄斑水肿之间存在显著关系。在非缺血性眼中，最后检查时，黄斑水肿患者中无PVD或伴有玻璃体黄斑粘连的部分PVD的发生率（76%，33只眼中25只）显著高于无黄斑水肿的眼（25%，51只眼中13只）（P<0.01）。
完全PVD可能预防严重CRVO眼中视网膜或视盘新生血管形成。玻璃体黄斑粘连可能导致轻度CRVO眼中持续性黄斑水肿。
