Perronne C
Service des maladies infectieuses et tropicales, Hôpital Raymond-Poincaré, Garches.
Rev Prat. 1995 Mar 15;45(6):729-32.
Mycobacterial infections are the main cause of bacterial infections during HIV infection. The HIV infection epidemic contributed to the worldwide resurgence of the tuberculous endemic. The clinical presentation of tuberculosis is often atypical and extrapulmonary. The general guidelines for treatment are not modified, but HIV infection often worsens the tolerance of treatment. A poor compliance to treatment is the main cause of relapse or of selection of resistant mutants. The two main points for the control of tuberculosis in the era of HIV are a free access of patients to antituberculosis drugs, and a surveillance of the compliance until treatment is completed. Atypical mycobacteria, mainly represented by Mycobacterium avium, are bacteria from the environment, poorly virulent, responsible for infections occurring late in the course of AIDS. Current treatments use combinations including clarithromycin.
分枝杆菌感染是HIV感染期间细菌感染的主要原因。HIV感染流行导致结核病地方病在全球范围内卷土重来。结核病的临床表现通常不典型且为肺外表现。治疗的一般指南并未改变,但HIV感染常常会使治疗耐受性变差。治疗依从性差是复发或耐药突变株产生的主要原因。HIV时代控制结核病的两个要点是患者可免费获得抗结核药物,以及在治疗完成前对依从性进行监测。非典型分枝杆菌,主要以鸟分枝杆菌为代表,是来自环境的细菌,毒力较弱,可导致艾滋病病程后期发生感染。目前的治疗采用包括克拉霉素在内的联合用药。