Grundemar L, Håkanson R
Department of Clinical Pharmacology, Lund University Hospital, Sweden.
Trends Pharmacol Sci. 1994 May;15(5):153-9. doi: 10.1016/0165-6147(94)90076-0.
Neuropeptide Y was isolated in 1982 and has since attracted considerable interest. It is widely distributed in central and peripheral neurones and can produce a multitude of biological effects in the brain and the periphery. For example, the peptide has been associated with stimulation of food and water intake, control of mood, and regulation of central autonomic functions. In the periphery, sympathetic neuropeptide Y plays a role as a vasopressor and vasoconstrictor. Neuropeptide Y acts on at least three distinct receptor types, referred to a Y1, Y2 and Y3. This review by Lars Grundemar and Rolf Håkanson focuses on some neuropeptide Y-dependent mechanisms that may be implicated in certain disorders and may be promising targets for drugs active at neuropeptide Y receptors.
神经肽Y于1982年被分离出来，自那时起便引起了广泛关注。它广泛分布于中枢和外周神经元中，并能在大脑和外周产生多种生物学效应。例如，该肽与刺激食物和水的摄入、情绪控制以及中枢自主功能的调节有关。在外周，交感神经肽Y作为一种血管升压剂和血管收缩剂发挥作用。神经肽Y作用于至少三种不同的受体类型，即Y1、Y2和Y3。拉尔斯·格伦德马尔和罗尔夫·哈坎松撰写的这篇综述聚焦于一些可能与某些疾病有关且可能成为神经肽Y受体活性药物的有前景靶点的神经肽Y依赖性机制。
