Delon-Martin C, Vogt C, Chignier E, Guers C, Chapelon J Y, Cathignol D
INSERM, Unité 281, Lyon, France.
Ultrasound Med Biol. 1995;21(1):113-9. doi: 10.1016/0301-5629(94)00095-6.
Sclerotherapy of superficial varicose veins is now performed with chemical agents since physical agents have given only poor clinical results. We investigated the possibility of using high intensity focused ultrasound energy to achieve this goal in an animal model, the rat femoral vein. A specially designed probe delivering ultrasonic energy at a central frequency of 7.31 MHz was constructed and evaluated. Femoral veins of six rats were surgically exposed to a set of between four and seven 3-s exposures at 1-mm increments at a power level of 167 W/cm2. At 2 days following the irradiation, control veins were patent while occlusive thrombus was documented by Doppler flow and histological studies in all six of the irradiated veins. No damage to the surrounding soft tissues was noted. We concluded that high-intensity focused ultrasound can be used to induce thrombosis in this animal model.
由于物理方法在临床应用中效果不佳，目前浅表静脉曲张的硬化疗法采用化学药物进行。我们在大鼠股静脉这一动物模型中研究了使用高强度聚焦超声能量来实现这一目标的可能性。我们构建并评估了一个专门设计的探头，其中心频率为7.31MHz，可传递超声能量。通过手术暴露六只大鼠的股静脉，以167W/cm²的功率水平，以1mm的增量进行一组4至7次每次3秒的照射。照射后2天，对照静脉通畅，而通过多普勒血流和组织学研究证实，所有六条照射静脉均形成了闭塞性血栓。未观察到周围软组织受损。我们得出结论，在该动物模型中，高强度聚焦超声可用于诱导血栓形成。
