Radiation treatment for rectal cancer.

Radiation treatment is widely used in the management of adenocarcinomas of the rectum, either alone or more frequently as part of multimodality treatment protocols. External beam radiation is capable of eradicating about one-third of bulky but mobile primary rectal cancers and is an alternative to be considered when standard surgery is not possible. Endorectal irradiation, either alone or combined with external beam treatment, has proved highly effective for selected superficial cancers of the distal rectum. Irradiation alone or in conjunction with cytotoxic chemotherapy appears to reduce the risk of tumor progression at the primary site or in regional lymph nodes when combined with local surgical excisions that preserve anorectal function. The treatment of recurrent and metastatic cancer frequently provides palliation, although cure by irradiation is rare.