[Pathogenesis of stomach carcinoma--significance of nitrates, N-nitroso compounds, nutritional factors and Helicobacter pylori-induced chronic active and chronic atrophic gastritis].

Epidemiological data on gastric cancer, time trends and histological classification are reviewed. Known models on gastric carcinogenesis including the pathogenetic importance of nitrates and N-nitroso compounds and protective effects of dietary components are discussed and recent evidence on Helicobacter pylori (Hp) induced chronic active gastritis, its progression to chronic atrophic gastritis and its role in gastric carcinogenesis is summarized. Epidemiological, clinical and pathological support for a causal relationship of Hp and gastric carcinoma is included in a new multistep model on aetiopathogenesis of gastric cancer. The follow-up of patients at risk as well as the question of cancer prevention by Hp eradication are mentioned.