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无症状性颈动脉病变手术治疗的获益-风险评估

[Benefit-risk assessment of surgical treatment of asymptomatic carotid lesions].

作者信息

Hohlbach G, Meffert R

机构信息

Marienhospital Herne, Ruhr Universität Bochum.

出版信息

Zentralbl Chir. 1995;120(3):186-94.

PMID:7754719
Abstract

In this review we draw a conclusion on the benefit and risks of the operation of asymptomatic stenotic lesions of the carotid artery referring to different pro- and retrospective studies. Long-term follow up observations on high grade carotid stenosis (> 80%) revealed an incidence of ipsilateral strokes of 2.5% per year [38], whereas after operation the incidence has been reduced to 0.2-0.5% per year [20]. The characteristics, the clinical significance of stenotic carotid lesions and the diagnostical features are summarized. Nowadays a perioperative mortality rate of 1.1% and morbidity rate (stroke) of 1.6% can be expected in experienced vascular surgical departments. Even advocates of non-operative treatment, who demanded a combined perioperative mortality and morbidity rate below 3% perceive that a prognostical benefit has been achieved within the first year after the operation. We therefore recommend the prophylactic operation for patients with asymptomatic high grade (> 80%) carotid stenosis, in ulcerative and smooth plaques, in stenosis of the contralateral side and prior or simultaneous with bypass operation, whenever there is a high expectation of life and low anaesthetic risk.

摘要

在本综述中,我们参考不同的前瞻性和回顾性研究,对无症状性颈动脉狭窄病变手术的益处和风险得出结论。对重度颈动脉狭窄(> 80%)的长期随访观察显示,同侧卒中的发生率为每年2.5%[38],而手术后该发生率已降至每年0.2 - 0.5%[20]。总结了颈动脉狭窄病变的特征、临床意义及诊断特点。如今,在经验丰富的血管外科科室,围手术期死亡率可预期为1.1%,发病率(卒中)为1.6%。即使是那些要求围手术期死亡率和发病率合计低于3%的非手术治疗倡导者也认识到,在手术后的第一年就已实现了预后益处。因此,我们建议,对于无症状性重度(> 80%)颈动脉狭窄患者,无论溃疡斑块还是光滑斑块、对侧狭窄、在旁路手术之前或同时进行手术,只要预期寿命长且麻醉风险低,都应进行预防性手术。

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