Larrue V, Dupui P, Pavy-Le Traon A, Allavoine T, Géraud G, Bès A
Laboratoire d'hémodynamique cérébrale, CHU de Rangueil, Toulouse.
Arch Mal Coeur Vaiss. 1994 Aug;87(8):997-1000.
Cerebral blood flow (CBF) was measured in 13 subjects (4 men and 9 women, mean age +/- SD = 63 +/- 7) with moderate, uncomplicated and untreated hypertension and 11 normotensive subjects (6 men and 5 women, mean age +/- SD = 66 +/- 5). A second CBF measurement was performed in hypertensive subjects after a 60 days randomized double blind treatment with either captopril, 75 mg a day (n = 8) or placebo (n = 5). CBF was quantified using the 133Xe inhalation technic and 16 stationary detectors by hemisphere. Comparison of CBF values between hypertensive subjects before treatment and normotensive subjects demonstrated a decrease of CBF in the hypertensive group (49 +/- 9 vs 72 +/- 14 ml/100 g/min; p < 0.001). After the trial the results in the captopril group showed a significant fall in systolic (p < 0.001) and diastolic (p < 0.05) blood pressure and a significant increase in CBF (60 +/- 14 vs 49 +/- 11 ml/100 g/min; p < 0.05). In the placebo group there was no change in blood pressure and CBF (Table). [Table; see text] Our results demonstrate a decrease in CBF of uncomplicated and untreated elderly hypertensive subjects. This decrease is reversible under chronic treatment with captopril.
对13名患有中度、未并发且未经治疗的高血压患者（4名男性和9名女性，平均年龄±标准差=63±7岁）和11名血压正常的受试者（6名男性和5名女性，平均年龄±标准差=66±5岁）测量了脑血流量（CBF）。对高血压患者进行了为期60天的随机双盲治疗，一组每天服用75毫克卡托普利（n=8），另一组服用安慰剂（n=5），之后再次测量他们的CBF。使用133Xe吸入技术和16个固定探测器按半球对CBF进行量化。比较治疗前高血压患者和血压正常受试者的CBF值，结果显示高血压组的CBF有所下降（49±9 vs 72±14毫升/100克/分钟；p<0.001）。试验结束后，卡托普利组的结果显示收缩压（p<0.001）和舒张压（p<0.05）显著下降，CBF显著增加（60±14 vs 49±11毫升/100克/分钟；p<0.05）。安慰剂组的血压和CBF没有变化（见表）。[表；见正文]我们的结果表明，未并发且未经治疗的老年高血压患者的CBF会下降。在卡托普利的长期治疗下，这种下降是可逆的。
