Carroll R T, Lust M R, Kim K S, Doyle P D, Emmerling M R
Parke-Davis Pharmaceutical Research, Division of Warner-Lambert Company, Ann Arbor, Michigan 48106, USA.
Biochem Biophys Res Commun. 1995 May 16;210(2):345-9. doi: 10.1006/bbrc.1995.1667.
We investigated the levels of amyloid precursor protein (APP) and beta-amyloid peptide (A beta) in the cerebrospinal fluid (CSF) from 110 individuals ranging in age from newborn to 82-years old to analyze their regulation with age. These samples were segregated into two groups; one group contained CSF samples from patients with diagnosed CNS abnormalities and the second group contained CSF samples from patients with no known CNS disorders. The presence of APP and A beta was detected in all ages and from both CSF groups. No significant difference in the average level of A beta or APP was noted from either group with a change in age. However, a positive correlation was found to exist between levels of APP and A beta in individuals 25 years and older, suggesting that APP and A beta processing in the CSF is developmentally regulated. This observation was observed for both CSF groups.
我们研究了110名年龄从新生儿到82岁的个体脑脊液（CSF）中淀粉样前体蛋白（APP）和β-淀粉样肽（Aβ）的水平，以分析它们随年龄的调节情况。这些样本被分为两组；一组包含来自诊断为中枢神经系统（CNS）异常患者的脑脊液样本，另一组包含来自无已知中枢神经系统疾病患者的脑脊液样本。在所有年龄段以及两组脑脊液样本中均检测到APP和Aβ的存在。两组中Aβ或APP的平均水平均未随年龄变化而出现显著差异。然而，在25岁及以上个体中发现APP和Aβ水平之间存在正相关，这表明脑脊液中APP和Aβ的加工过程受到发育调控。两组脑脊液样本均观察到了这一现象。
