Khattech R, Ben Othman M, Ben Romdhane K, Gamoudi A, Ammar A
Laboratoire d'Anatomie et de Cytologie Pathologique, Institut Salah Azaiz, Tunis, Tunisie.
Ann Pathol. 1995;15(2):138-41.
Myoepithelial cell tumors of the breast are rare. They present diagnostic difficulties not only on frozen sections but also after fixation and paraffin embedding. These tumors can give rise to a wide range of clinical evolution... Treatment vary from simple excision for myoepitheliosis to mastectomy with axillary node dissection for malignant myoepitheliomas. Large excision is necessary for adenomyoepitheliomas because of the risk of recurrence and, more uncommonly, their proclivity to metastasis. We report the case of breast myoepithelioma in a 42 years old woman. The tumor was clinically, radiologically and macroscopically well demarcated. Histologically the tumor was composed of myoepithelial cells with few cellular atypias and a low mitotic activity. Tumor cells expressed vimentin, actin, S100 protein and cytokeratin. This particular immunohistochemical phenotype allows the differential diagnosis with other breast tumors.
乳腺肌上皮细胞瘤较为罕见。它们不仅在冰冻切片时,而且在固定和石蜡包埋后都存在诊断困难。这些肿瘤可呈现出广泛的临床病程……治疗方法从针对肌上皮病的单纯切除到针对恶性肌上皮瘤的乳房切除术加腋窝淋巴结清扫术不等。由于腺肌上皮瘤有复发风险,且更罕见的是有转移倾向,因此需要进行广泛切除。我们报告了一名42岁女性乳腺肌上皮瘤的病例。该肿瘤在临床、放射学和大体上界限清楚。组织学上,肿瘤由肌上皮细胞组成,细胞异型性少,有丝分裂活性低。肿瘤细胞表达波形蛋白、肌动蛋白、S100蛋白和细胞角蛋白。这种特殊的免疫组化表型有助于与其他乳腺肿瘤进行鉴别诊断。