Dunnett S B
MRC Cambridge Centre for Brain Repair, University of Cambridge, UK.
Behav Brain Res. 1995 Jan 23;66(1-2):133-42. doi: 10.1016/0166-4328(94)00134-2.
Intrastriatal grafts of nigral and adrenal tissues have been found to be effective in alleviating many of the simple motor and sensorimotor deficits associated with lesions of the nigrostriatal dopamine system. However, the mechanisms by which such grafts exert their effects may be less specific than originally conceived, and both pharmacological and trophic actions play an essential role. Damage to intrinsic cortico-striatal circuits are unlikely to prove similarly amenable to such diffuse mechanisms of repair. Nevertheless, striatal grafts have been found to alleviate cognitive and motor deficits after excitotoxic lesions of the neostriatum. Accumulating evidence suggests that in this particular case many aspects of functional recovery may indeed be attributable to the striatal grafts providing an effective functional reconstruction of damaged neuronal circuits within the host brain.
已发现黑质和肾上腺组织的纹状体内移植在减轻许多与黑质纹状体多巴胺系统损伤相关的简单运动和感觉运动缺陷方面是有效的。然而，此类移植发挥作用的机制可能不像最初设想的那样具有特异性，药理学作用和营养作用都起着至关重要的作用。内源性皮质 - 纹状体回路的损伤不太可能同样适合这种弥散性修复机制。尽管如此，已发现纹状体移植可减轻新纹状体兴奋性毒性损伤后的认知和运动缺陷。越来越多的证据表明，在这种特殊情况下，功能恢复的许多方面可能确实归因于纹状体移植在宿主脑内对受损神经元回路进行了有效的功能重建。
