Mandelkow E, Mandelkow E M
Max Planck Unit for Structural Molecular Biology, Hamburg, Germany.
Curr Opin Cell Biol. 1995 Feb;7(1):72-81. doi: 10.1016/0955-0674(95)80047-6.
Microtubule research is becoming increasingly diverse, reflecting the many isoforms and modifications of tubulin and the many proteins with which microtubules interact. Recent advances are particularly visible in four areas: microtubule motor proteins (their structures, stepping modes, and forces); microtubule nucleation (the roles of centrosomes and gamma-tubulin); tubulin folding (mediated by cytoplasmic chaperones); and the expanding list of microtubule-associated proteins, knowledge of their phosphorylation states, and information on their effects on microtubule dynamics.
微管研究正变得日益多样化，这反映了微管蛋白的多种异构体和修饰形式，以及与微管相互作用的众多蛋白质。最近的进展在四个领域尤为明显：微管运动蛋白（其结构、步移模式和作用力）；微管成核（中心体和γ-微管蛋白的作用）；微管蛋白折叠（由细胞质伴侣介导）；以及不断增加的微管相关蛋白列表、它们的磷酸化状态信息以及它们对微管动力学影响的信息。
