Yokoyama J, Ikawa H, Endow M, Fuchimoto Y, Watanabe K, Hosoya R, Nishimura K
Department of Pediatric Surgery, School of Medicine, Keio University, Tokyo, Japan.
Eur J Pediatr Surg. 1995 Feb;5(1):23-6. doi: 10.1055/s-2008-1066156.
Recently we performed multi-modal therapy including chemotherapy with bone marrow transplantation (BMT), surgery, and local irradiation in the treatment of advanced neuroblastoma. As a result, all Stage III patients survived, and 4 out of 8 Stage IV patients who underwent our original systemic gross complete resection achieved long-term survival, 4y8m, 5y8m, 5y6m and 5y5m, respectively. Long-term survival patients were treated by local irradiation, brain surgery and intensive induction chemotherapy before primary site operation, and when resolution of distant metastases was obtained, the primary site was resected completely, followed by postoperative supralethal chemotherapy with BMT. The purpose of this report is to elucidate the role of surgery in advanced neuroblastoma based on our clinical results.
最近，我们采用了多模式疗法，包括化疗联合骨髓移植（BMT）、手术及局部放疗，用于治疗晚期神经母细胞瘤。结果显示，所有III期患者均存活，在接受我们最初的全身大体完全切除手术的8例IV期患者中，有4例实现了长期存活，分别为4年8个月、5年8个月、5年6个月和5年5个月。长期存活患者在原发部位手术前接受了局部放疗、脑外科手术及强化诱导化疗，当远处转移灶消失后，对原发部位进行了完全切除，随后进行了术后超致死剂量化疗联合BMT。本报告的目的是基于我们的临床结果阐明手术在晚期神经母细胞瘤治疗中的作用。
