Oku Y, Dick T E
Department of Clinical Physiology, Kyoto University, Japan.
Neuroreport. 1995 Jan 26;6(2):379-83. doi: 10.1097/00001756-199501000-00037.
Superior laryngeal nerve (SLN) stimulation during expiration prolongs the respiratory cycle in decerebrate, vagotomized and paralysed cats. In a few animals, however, the cycle can be terminated prematurely by the same stimulus. We developed a mathematical model of the respiratory neural network to stimulate these responses. The model contained inspiratory decrementing (I-DEC), and augmenting (I-AUG) and expiratory decrementing (E-DEC), and augmenting (E-AUG) neurones. Connections were based on published findings. SLN stimulation during late expiration prolonged the cycle when it was assumed to excite principally E-DEC neurones, whereas it terminated the cycle prematurely when it was assumed to excite both I-DEC and E-DEC neurones. Therefore, phase-resetting depends on the differential strength of afferent connections on the network's elements.
在去脑、迷走神经切断并麻痹的猫中，呼气时刺激喉上神经（SLN）可延长呼吸周期。然而，在少数动物中，相同的刺激可使呼吸周期提前终止。我们建立了一个呼吸神经网络的数学模型来模拟这些反应。该模型包含吸气递减（I-DEC）、吸气增强（I-AUG）、呼气递减（E-DEC）和呼气增强（E-AUG）神经元。其连接基于已发表的研究结果。当假定在呼气后期刺激SLN主要兴奋E-DEC神经元时，可延长呼吸周期；而当假定刺激SLN同时兴奋I-DEC和E-DEC神经元时，则会使呼吸周期提前终止。因此，相位重置取决于网络元件上传入连接的差异强度。
