de Zegher F, Van den Bershe G, Dumoulin M, Gewillig M, Daenen W, Devlieger H
Department of Pediatrics, University Hospital Gasthuisberg, University of Leuven, Belgium.
Acta Paediatr. 1995 Feb;84(2):213-4. doi: 10.1111/j.1651-2227.1995.tb13614.x.
The infusion of dopamine, a hypophysiotropic catecholamine, which inhibits release of thyroid stimulating hormone (TSH), is the inotropic therapy of first choice in neonatal intensive care. Newborns with primary hypothyroidism are at increased risk of cardiocirculatory morbidity and are screened by measuring serum TSH concentrations. In an infant with both congenital heart disease and neonatal hypothyroidism, withdrawal of dopamine infusion was documented to evoke a doubling of serum TSH levels within 40 min, a finding suggestive of an inhibitory effect of dopamine administration on neonatal TSH hypersecretion. As a result, dopamine therapy may be a pitfall in TSH screening for neonatal hypothyroidism.
多巴胺是一种促垂体的儿茶酚胺，可抑制促甲状腺激素（TSH）的释放，在新生儿重症监护中，多巴胺输注是首选的强心治疗方法。原发性甲状腺功能减退的新生儿发生心脏循环疾病的风险增加，可通过测量血清TSH浓度进行筛查。在一名患有先天性心脏病和新生儿甲状腺功能减退的婴儿中，记录到停止多巴胺输注后40分钟内血清TSH水平翻倍，这一发现提示多巴胺给药对新生儿TSH分泌过多有抑制作用。因此，多巴胺治疗可能是新生儿甲状腺功能减退症TSH筛查中的一个陷阱。
