位于Xp11.21的DXS423E基因逃避X染色体失活。
The DXS423E gene in Xp11.21 escapes X chromosome inactivation.
作者信息
Brown C J, Miller A P, Carrel L, Rupert J L, Davies K E, Willard H F
机构信息
Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
出版信息
Hum Mol Genet. 1995 Feb;4(2):251-5. doi: 10.1093/hmg/4.2.251.
The DXS423E gene has been localized to Xp11.21 and is expressed in somatic cell hybrids retaining either the human active or inactive X chromosome, demonstrating that DXS423E escapes X chromosome inactivation. The XE169 (DXS1272E or SMCX) gene that escapes X chromosome inactivation is also located in Xp11.21-11.22 and maps within the same YAC as DXS423E. Thus the DXS423E and XE169 genes define a new region in the proximal short arm of the X chromosome that is not subject to X chromosome inactivation, supporting a regional basis for escape from inactivation.
DXS423E基因已被定位到Xp11.21，并且在保留人类活性或失活X染色体的体细胞杂种中表达，这表明DXS423E逃避了X染色体失活。逃避X染色体失活的XE169（DXS1272E或SMCX）基因也位于Xp11.21 - 11.22，并且与DXS423E位于同一个酵母人工染色体（YAC）内。因此，DXS423E和XE169基因定义了X染色体短臂近端一个新的区域，该区域不受X染色体失活的影响，这支持了逃避失活的区域基础。
Zotero 插件