乙硫氨酸抗性HeLa S3变体的Mer表型 - Suppr

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A Mer- phenotype of ethionine-resistant HeLa S3 variants.

作者信息

Okada G, Reungmaneepaitoon S, Nakano N, Nomura T, Tokuyama H, Ryoyama K, Yamaguchi K, Kameyama T

出版信息

In Vitro Cell Dev Biol Anim. 1995 Mar;31(3):168-70. doi: 10.1007/BF02639428.

DOI:10.1007/BF02639428

PMID:7757296

Abstract

摘要

相似文献

A Mer- phenotype of ethionine-resistant HeLa S3 variants.乙硫氨酸抗性HeLa S3变体的Mer表型

In Vitro Cell Dev Biol Anim. 1995 Mar;31(3):168-70. doi: 10.1007/BF02639428.

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N-methyl-N'-nitro-N-nitrosoguanidine-resistant HeLa S3 cells still have little O6-methylguanine-DNA methyltransferase activity and are hypermutable by alkylating agents.对N-甲基-N'-硝基-N-亚硝基胍具有抗性的海拉S3细胞仍然几乎没有O6-甲基鸟嘌呤-DNA甲基转移酶活性，并且对烷基化剂高度易变。

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Increased O6-methylguanine-DNA methyltransferase activity and reduced mutability in 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2- chloroethyl)-3-nitrosourea-resistant HeLa S3 cells.1-(4-氨基-2-甲基-5-嘧啶基)甲基-3-(2-氯乙基)-3-亚硝基脲抗性的HeLa S3细胞中O6-甲基鸟嘌呤-DNA甲基转移酶活性增加及突变率降低

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Expression of the O6-methylguanine-DNA methyltransferase gene MGMT in MER+ and MER- human tumor cells.

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Genomic differences between O6-methylguanine-DNA methyltransferase proficient (Mex+) and deficient (Mex-) cell lines: possible role of genetic and epigenetic changes in conversion of Mex+ into Mex-.O6-甲基鸟嘌呤-DNA甲基转移酶 proficient（Mex+）和 deficient（Mex-）细胞系之间的基因组差异：遗传和表观遗传变化在Mex+向Mex-转化中的可能作用

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Differences in induction of sister chromatid exchanges in MNNG-resistant HeLa S3 Mer- cell lines.

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MNNG-induced partial phenotypic reversion of Mer- cells.

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Quantitation of O6-methylguanine-DNA methyltransferase in HeLa cells.HeLa细胞中O6-甲基鸟嘌呤-DNA甲基转移酶的定量分析。

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Methylation hot spots in the 5' flanking region denote silencing of the O6-methylguanine-DNA methyltransferase gene.5'侧翼区域的甲基化热点表明O6-甲基鸟嘌呤-DNA甲基转移酶基因沉默。

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本文引用的文献

Multiple species of mammalian S-adenosylmethionine synthetase. Partial purification and characterization.多种哺乳动物的S-腺苷甲硫氨酸合成酶。部分纯化及特性鉴定。

Biochemistry. 1981 Feb 17;20(4):934-40. doi: 10.1021/bi00507a045.

DNA cross-linking and monoadduct repair in nitrosourea-treated human tumour cells.亚硝基脲处理的人肿瘤细胞中的DNA交联与单加合物修复

Nature. 1980 Dec 25;288(5792):727-9. doi: 10.1038/288727a0.

MNNG-induced partial phenotypic reversion of Mer- cells.

Carcinogenesis. 1987 Oct;8(10):1449-53. doi: 10.1093/carcin/8.10.1449.

Nicotinamide starvation and inhibition of poly(ADP-ribose) synthesis enhance the induced mutation in Chinese hamster V79 cells.烟酰胺饥饿和聚（ADP - 核糖）合成的抑制增强了中国仓鼠V79细胞中的诱导突变。

J Radiat Res. 1987 Sep;28(3):191-203. doi: 10.1269/jrr.28.191.

Elevation of c-myc protein by DNA strand breakage.

Oncogene. 1989 Dec;4(12):1497-502.

Isolation and structural characterization of a cDNA clone encoding the human DNA repair protein for O6-alkylguanine.编码人O6-烷基鸟嘌呤DNA修复蛋白的cDNA克隆的分离与结构表征

Proc Natl Acad Sci U S A. 1990 Jan;87(2):686-90. doi: 10.1073/pnas.87.2.686.

Molecular cloning and biological characterization of the human excision repair gene ERCC-3.人类切除修复基因ERCC-3的分子克隆与生物学特性分析

Mol Cell Biol. 1990 Jun;10(6):2570-81. doi: 10.1128/mcb.10.6.2570-2581.1990.

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