Giaume C, Venance L
INSERM U114, Collège de France, Paris.
Perspect Dev Neurobiol. 1995;2(4):335-45.
In mammalian brain, glia are likely the most abundant and widespread cell population connected by gap junctions. Here, we summarize recent findings concerning the distribution, expression, and regulation of gap junction proteins in different glial subtypes and their possible roles in modulating the function of the nervous system. Intercellular communication through gap junctions is proposed to be one of the required interactions between cells during development, and we discuss how gap junctions could participate in development of brain glial cells.
在哺乳动物大脑中，神经胶质细胞可能是通过缝隙连接相连的数量最多、分布最广的细胞群体。在此，我们总结了有关缝隙连接蛋白在不同神经胶质细胞亚型中的分布、表达和调节及其在调节神经系统功能中可能作用的最新研究结果。通过缝隙连接进行的细胞间通讯被认为是发育过程中细胞间必需的相互作用之一，并且我们讨论了缝隙连接如何参与脑胶质细胞的发育。
