五元环氮杂糖作为来自斜卧青霉的α-L-鼠李糖苷酶（柚苷酶）的有效抑制剂。
Five-membered ring azasugars as potent inhibitors of alpha-L-rhamnosidase (naringinase) from Penicillium decumbens.
作者信息
Provencher L, Steensma D H, Wong C H
机构信息
Department of Chemistry, Scripps Research Institute, La Jolla, CA 92037, USA.
出版信息
Bioorg Med Chem. 1994 Nov;2(11):1179-88. doi: 10.1016/s0968-0896(00)82069-6.
PMID:7757415
Abstract
Five-membered ring azasugars with the L-rhamnose configuration were synthesized as inhibitors of alpha-L-rhamnosidase from Penicillium decumbens. All compounds tested were in the microM or sub-microM range. Substitution at the nitrogen shifted the inhibition mechanism from mixed to competitive.
摘要
合成了具有L-鼠李糖构型的五元环氮杂糖，作为来自斜卧青霉的α-L-鼠李糖苷酶的抑制剂。所有测试化合物的浓度范围为微摩尔或亚微摩尔级。氮原子上的取代使抑制机制从混合型转变为竞争性。
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