Schor N F, Nylander K D, Constantine T, Schwartz M C
Department of Pediatrics, University of Pittsburgh, PA, USA.
Brain Res. 1995 Feb 27;673(1):175-9. doi: 10.1016/0006-8993(95)00004-a.
It has been suggested that G0 and Gi play a role in the collapse of axonal growth cones and the retraction of neurites. We have studied the G-protein content of neuroblastoma cells undergoing neurite outgrowth and subsequent retraction in response to neocarzinostatin (NCS). Stimulators of G0 and Gi have no effect upon neurite outgrowth or retraction and the cellular content of G0 and Gi does not change during the course of these morphological phenomena. Modulation of G-protein content, therefore, most likely does not play a role in this process.
有人提出，G0和Gi在轴突生长锥的塌陷和神经突的回缩中起作用。我们研究了神经母细胞瘤细胞在新制癌菌素（NCS）作用下经历神经突生长和随后回缩过程中的G蛋白含量。G0和Gi的刺激剂对神经突生长或回缩没有影响，并且在这些形态学现象过程中G0和Gi的细胞含量没有变化。因此，G蛋白含量的调节很可能在这个过程中不起作用。
